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KMID : 1156220080340040285
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Journal of Environmental Health Sciences
2008 Volume.34 No. 4 p.285 ~ p.291
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A Study on the Effect of Chitin, Chitosan and Dithiocarbamate Chitosan on the Nickel Toxicity in Rat liver
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Yoo Il-Su
Choi Kyung-soon
Ryu Moon-Hee
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Abstract
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This study was performed to investigate the effects of Chitosan on the nickel poisoning in rats. In the study, 150 male Sprague-Dawley were used. The experimental groups were divided into four: A (30 ㎎/ℓ nickel), B (30 ㎎/ℓ nickel+0.2% Chitin, Chitosan and Dithiocarbamate Chitosan), C (30 ㎎/ℓ nickel+0.4% Chitin, Chitosan and Dithiocarbamate Chitosan), D (30 ㎎/ℓ nickel+0.8%Chitin, Chitosan and Dithiocarbamate Chitosan). The results were as flows; 1. The nickel concentration in the livers of the control group (A) was 0.153-0.186 ㎎/㎏ but the nickel concentration in the livers of the experimental decreased during the experimental period (P<0.05). 2. Metallothionenin levels in rat liver were 2.77-3.25 ug/g wet,wt in control group (A), but were 2.89-3.51 ug/g wet,wt (B), 2.97-3.62 ug/g wet,wt (C), 2.68-3.68 ug/g wet,wt (D). Resectively in the experimental groups. The experimental groups were inclined to increase compare to the control group (P<0.05). In conclusion, this study revealed a preventive effect of Chitin, Chitosan and Dithiocarbamate Chitosan against nickel toxicity.
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KEYWORD
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nickel, preventive effect, toxicity, chitin, chitosan, Dithiocarbamate Chitosan, liver
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